Abstract
In this piece of study one case evaluated relevant to the dose calculation in which six formulas utilized for calculation of optimal doses and comparison between these formulas as well as beauty of all formulas. The different formulas used like on the basis of age includes Young rules, Dilling rules, Bastedo rules, Crowling, on the basis of weight Clark and Majid formula used and for Body Surface Area Mosteller formula utilized. The result of the current study purports for one patient of Paracetamol dose in which Young formula result is 250 mg, Dilling 300mg, Bastedo 250mg, Crowling 270.9mg, on weight basis 278.5mg by Clark and Majid rule also 278.5 and 329mg by Mosteller Body Surface Area formula, the mean of the current result is 279.4mg that is nearest to weight formula considered as better and BSA formula shows 329mg that is in the category of therapeutic window because in British National Formulary Paracetamol dose ranges from 250-500mg and some authors reported Dilling rule is good due to simplicity and brevity. The current study concluded Dilling rule is the simplest one, weight base is nearest to average range and the most appropriate formula is BSA but slight lengthy in calculation. Dose calculation play crucial role in clinical condition of the patient and proper formula should be selected in order to get better therapeutic outcomes.
Highlights
The mean range of six formulas including on the basis of age, weight and Body Surface Area is 1678.4mg
The result of the current study purports for one patient of Paracetamol dose in which Young rule result is 250 mg, Dilling 300mg, Bastedo 250mg, Crowling 270.4mg, on weight basis 278.5mg by Clark rule and similar by Majid rules and 329mg by Body Surface Area Mosteller rules, the mean of the current result is 279.4mg that is nearest to weight base formula that’s why considered as better for this case
On other hand BSA Mosteller rules shows 329mg that is an ideal range for clinical condition of the patient and in the range recommended by BNF sufficient for patient better therapeutic outcome
Summary
In a similar way for 6-12 years child, the dose will be 250-500mg per 24 hours, in rest of dose 375mg will show better therapeutic outcome that is considered as therapeutic window, less than this range shows sub-therapeutic effect and more than therapeutic window shows toxic outcomes mean adverse responses [1] (Figure 1). It plays crucial role in division and differentiation of dose of a drug for pediatrics, geriatrics or infants. Loss of both patient health and wealth on therapy and no actual therapeutic response achieved
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