Derivation of a Unique Body Surface Area (Bsa) Formula for Calculation of Relatively Safe Doses of Dog and Human Anticancer Drugs

Abstract

The safety of anticancer dosing has become a serious concern due to high incidence of life-threatening toxicity signs. More so, dogs are used as models of research for human cancers. In view of these a uniform body surface area (BSA) formula has been derived for human and dog with a view to having low, safe, effective therapeutic doses of anticancers. The derived formula (BSA=BW0.528 × H0.528 × K) was used to calculate BSAs of greyhound, toy, companion, terrier, hunting and working dogs and yielded low effective therapeutic doses of dacarbazine, asparaginase, streptozotocin, dactinomycin, epirubicine and prednisolone. Hunting and working dogs have high body weight, BMI and BSAs similar to that of human and may be prone to obesity and obesity associated diseases. Whereas BSAs and doses of anticancer agents of light and relatively tall dogs are relatively higher in comparison with that of short and light dogs. Greyhounds have higher BSA in comparison with toys, companions and terriers. Working breeds of dog such as Treeing Walker Coon haired (65.0 kg), Great Swiss mountain dog (59.0 kg), longhaired St. Bernard (55.0 kg), French Mastiff (50.0 kg) and female Komondor (59.0 kg) have same BSA values with humans weighing 51.3, 46.7, 44.8, 44.0 and 43.0 kg, respectively. Calculated common exponent (0.528) for body weight and height may be the common relationship between basal metabolism of dog and human.