Comparative study between the effects of some dietary sources and metformin drug on weight reduction in obese rats

Abstract

The worldwide obesity epidemic has produced profound effects on public health. Grain such as rice and oat may offer some protection against the early stage of obesity and the development of complications. The research aimed at comparative study between brown rice, germinated brown rice, and oat and metformin on overweight reduction in obese rats of lipid profiles (total cholesterol, triglycerides, low density lipoprotein (LDL-c), high density lipoprotein (HDL-c) and very low density lipoprotein (VLDL-c)) and liver function (Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)) in rats. This work was carried out on 60 adult male white albino rats (Sprague-Dawley strain) randomly classified into ten groups. The results indicate that the statistical analysis referred that the positive control group was significantly increased in feed intake, triglycerides, HDL/LDL-cholesterol and VLDL-cholesterol comparing with group (3) (188.43g and 98g), (123.8mg/dL and 117.3mg/dL), (5.42mg/dL and 0.439mg/dL), (24.767mg/dL and 23.467mg/dL). On the other hand, group (6) in the relative weight heart, kidney and liver was significantly decreased comparing with positive control group (0.417g and 0.517g–0.8g and 1.15g–3.51g and 5.65g). Data represented showed that the significant increase in positive control groups comparing with group (4) of total lipids and glucose (208mg/dL and 193.3mg/dL) and (97.5mg/dL and 76.5mg/dL), while the positive control group was significantly increased in total cholesterol, HDL-cholesterol, ALT and AST comparing with group (6) (84.333mg/dL and 56.333mg/dL), (18.5mg/dL and 7.167mg/dL), (23.16U/L and 13.5U/L), and (130.5U/L and 48.7U/L).