Abstract
This study was undertaken to evaluate the hypoglycemic and hypolipidemic effect of Momordica charantia (wild and hybrid variety) powder on alloxan induced type 2 diabetic male Long-Evans rats. Oral feeding of the M. charantia powder slightly decreased serum total cholesterol, triglyceride levels and LDL-cholesterol compared with wild, hybrid and standard drug. M. charantia wild variety showed more significant (p M. charantia did not show any significant effect on HDL-cholesterol and liver glycogen. Thus, results of the study prove that the wild variety of M. charantia fruit have potent antidiabetic and antilipidemic property.
Highlights
Diabetes mellitus (DM) is a major degenerative disease in the world today [1], affecting at least 15 million people and having complications which include hypertension, atherosclerosis and microcirculatory disorders [2]
Hyperglycemia and Hyperlipidemia is implicated as the cause for coronary heart diseases
The results of effect of powder of M. charantia 50% and 30% which are expressed as change in blood glucose level are shown in Table 1 & Figure 1 respectively
Summary
Diabetes mellitus (DM) is a major degenerative disease in the world today [1], affecting at least 15 million people and having complications which include hypertension, atherosclerosis and microcirculatory disorders [2]. Diabetes mellitus a heterogeneous group of disorders characterized by hyperglycemia, is one of the commonest endocrine and metabolic disorders affecting mankind all over the world. It is defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both [4,5]. The present research program was under taken to investigate hypoglycemic and hypolipidemic comparative activities of fruits powder of wild and hybrid Momordica charantia on alloxan induced diabetic model rats
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