Abstract
The aim of this study is to investigate the hypoglycemic and hypolipidemic effects of Coccinia cordifolia leaf and root powder on alloxan induced type 2 diabetic Long-Evans rats. Oral feeding of the C. cordifolia leaf and root powder slightly decreased serum total cholesterol, triglyceride levels and LDL-cholesterol as compared with leaf, root and standard drug. C. cordifolia leaf showed more significant (p < 0.05, 0.01 and 0.001) effect on blood glucose level when compared with root and standard drug (glibenclamide, 5 mg/kg). At the mean time, rats’ serum insulin level markedly increased; leaf does showed more significant (p < 0.05, 0.01 and 0.001) effect than glibenclamide control group and root powder feeding group. But C. cordifolia did not show any significant effect on HDL-cholesterol and liver glycogen after 21st day feeding. Thus, the results of the experimental study suggest that C. cordifolia possesses hypoglycemic and hypolipidemic effects and is able to ameliorate the diabetic state and can be served as a source of potent antidiabetic agent. In this comparative study, it was shown that leaf was better than root in the effects of hypoglycemic and hypolipidemic status. Key words: Type 2 diabetes mellitus, Coccinia cordifolia, alloxan, hypoglycemic, hypolipidemic, LDL-cholesterol and glibenclamide.
Highlights
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, abnormal lipid and protein metabolism along with specific long-term complications affecting the retina, kidney and nervous system (Bhagwat, 2006)
Plants are well known in traditional herbal medicine for their hypoglycemic activities, and available literature indicate that there are more than 800 plant species showing hypoglycemic activity (Rajagopal et al, 2008)
An attempt was made to assess the mode of anti-diabetic action of C. cordifolia
Summary
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, abnormal lipid and protein metabolism along with specific long-term complications affecting the retina, kidney and nervous system (Bhagwat, 2006). Hyperglycemia is an important factor in the development and progression of the complications of diabetes mellitus (Tiwari, 2005). The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction and failure of various organs (Lyra et al, 2006). Despite the presence of known anti-diabetic medicine in the pharmaceutical market, diabetes and the related complications continued to be a major medical problem. Some medicinal plants have been reported to be useful in diabetes worldwide and have been used empirically as anti-diabetic and anti-
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