Abstract
Compare fibrin glue (Tissucol(®)) and platelet-rich plasma in full-thickness mesh skin grafts in dogs. Eighteen dogs were used, divided into two groups: fibrin glue (FG) and platelet-rich plasma (PRP). In all the animals, a full-thickness 3x3 cm mesh skin graft was implanted. In the left limb, the biomaterial was place between the graft and the receptor bed, according to the group, while the right limb served as the control group. All the animals were evaluated clinically every 48 hours until the 14th day, using the variables of exudation, coloration, edema and cosmetic appearance. Three animals were evaluated histologically, on the third, seventh and tenth postoperative days, using the variables of fibroblasts, collagen, granulation tissue, microscopic integration-adherence and acute inflammation. Clinical evaluations showed that the group CF showed better scores for all variables compared to PRP group. On the histological evaluations PRP group had a higher presence of fibroblasts in the seventh and fourteenth days. The fibrin glue group was clinically superior to the platelet-rich group when used on full-thickness skin grafts in dogs.
Highlights
Reconstructions on distal lesions are made more complicated because of the scarcity of local tissue and the frequent association between orthopedic injuries and skin loss
Secondintention healing or skin traction are used for wounds involving less than 30% of the limb circumference[1].The method of bringing the wound edges together should only be used in situations in which no distorting or tensioning of the tissue occurs[2]
The experimental protocol was approved by the Ethics Committee for Use of Animals (CEUA) of UFMS, under no. 198/2008, at a meeting held on November 24, 2008
Summary
Reconstructions on distal lesions are made more complicated because of the scarcity of local tissue and the frequent association between orthopedic injuries and skin loss. Secondintention healing or skin traction are used for wounds involving less than 30% of the limb circumference[1].The method of bringing the wound edges together should only be used in situations in which no distorting or tensioning of the tissue occurs[2]. Skin grafts assist wound healing by replacing dermal collagen and providing biological occlusion and protection of the wound[3]. Meshing a skin graft reduces the chance of haematoma collection and allows good draping within a concavity. These qualities ensure good contact with the graft bed and good graft take. It allows fluid and blood to pass through the graft via multiple fine perforations, enabling earlier intra-operative application to the bed without haematoma collection[4]
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