Abstract
The maximum activity and intracellular distribution of NADP +-linked malic enzyme in brain of Mammalia, Aves, Reptilia, Amphibia and Pisces are reported. Malic enzyme activity was present in all animal brains investigated. Most of the enzyme activity was located in the mitochondrial fraction. In brain of endothermic animals the activity of malic enzyme was several-fold higher than in ectothermic animals. Other NADPH-producing enzymes (i.e. NADP +-linked isocitrate dehydrogenase and hexosemonophosphate shunt dehydrogenase) activities were essentially similar in all animal brains tested. However, the total potential capability of NADPH production was lower in ectothermic animals (due mainly to lower malic enzyme activity). It is suggested that the presence of NADP +-linked malic enzyme in the brain may be related mainly to mitochondrial metabolism, especially to maintain the mitochondrial pool of NADP + in reduced form.
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