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Abstract
The comparative cytogenetic and mutagenic effects between trivalent and hexavalent chromium were investigated. Five chromium compounds, K 2Cr 2O 7 and K 2CrO 4 containing Cr 6+, and Cr(CH 3COO) 3, Cr(NO 3) 3 and CrCl 3 containing Cr 3+, were examined for their ability to induce chromosomal damage in cultures of human leukocytes, for their reactivity with DNA by a rec-assay system and for mutagenicity in the E. coli Hs30R test system. Chromosome-breaking activity was significantly higher for the compounds with hexavalent than trivalent chromium, the efficiency being in the decreasing order K 2Cr 2O 7 > K 2CrO 4 >> Cr(CHCOO) 3 > Cr(NO 3) 3, CrCl 3. In the rec-assay and mutation assay, hexavalent (K 2Cr 2O 7 and K 2CrO 4) and trivalent Cr(CH 3COO) 3) compounds gave positive results, their mutagenic potential being higher in the same order of clastogenic magnitude.
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