Abstract
Chloroxylon swietenia DC is a traditional medicinal plant used to treat various disorders. To support its traditional utility as medicine, the present work aims at screening the antimicrobial activity and determining total phenolic and flavonoid contents with their antioxidant potential. Essential oils and methanolic extracts of leaves and bark were considered for the study. The antimicrobial activity was performed by two fold dilution assay. Antioxidant activity, total phenolic and flavonoid contents were determined by using standard methods. The essential oils were effective on gram positive than gram negative organisms with minimum inhibitory concentration (MIC) values ranging between 0.41 and 0.83 mg/mL (MIC < 1 mg/mL). Methanolic extracts were more effective than the essential oils (MIC−0.20 to 2.08 mg/mL) against bacterial strains. Essential oils and methanolic extracts were less effective on fungal strains as compared to bacterial strains. It was observed that essential oils from leaves and bark had higher phenolic and flavonoid contents than methanolic extracts. Correspondingly, higher 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing antioxidant power (FRAP) antioxidant activities were observed in essential oils. Chloroxylon swietenia contains antimicrobial and antioxidant components with respect to polyphenols in it. Therefore, the present study indicates the utility of this plant in the management of various diseases as traditional medicine.
Published Version
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