Abstract
According to the World Health Organization (WHO) guidelines for cancer patients with moderate or severe pain, morphine is the standard treatment for cancer pain. However, the use of morphine is sometimes accompanied by side effects such as constipation, emesis and drowsiness. Oxycodone, a series of opioids, interacts primarily with the μ-opioid receptor and has been used for opioid rotation. In the clinic, oxycodone has been used for pain management since 1917 and is widely acknowledged as an invaluable alternative to morphine. This review aims to compare the pharmacological profiles of oxycodone and morphine in a neuropathic pain-like state in mice.
Published Version
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