Abstract
Studies on a comparison of the biological activity of 19-nortestosterone and 17-hydroxyprogesterone derivatives were presented. Pituitary inhibiting androgenic and anabolic effects induced by progestational steroids in parabiotic rats were presented. Initial studies with parabiotic rats showed that these compounds produce hypertrophy of secondary male sex glands and an increase in levator ani muscle weight. The female parabiont underwent marked precocious sexual maturation. In comparing levator ani weights the 17-ethyl and 17-methyl nortestosterones were the only compounds with marked anabolic activity. Progestational steroids were rated as good to excellent in inhibition of human ovulation and in the treatment of dysmenorrhea. It was found that 17-methyl-19-nortestosterone appeared to be undesirably androgenic in many women while 17-ethyl-19-nortestosterone showed good anabolic activity with minimal androgenic effects.
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