Abstract
Background: Praval (coral) is a very usually occurring calcium form. It is rich source of calcium & minerals. As per text it can be converted into two formulas which are bhasma (calcinated ash) and pishti(powdered form without agni).These forms may have different rate of immersion. This needs to be studied.
 Aim: Pharmaceutical Standardization study of Praval Pishti & Praval Bhasma and comparative evaluation of their relative oral bioavailability.
 Materials and methods: The two formulations will be prepared from Praval (coral). By triturating with Gulab jala Praval Pishti will be prepared and by traditional Puta method Praval Bhasma will be prepared. The prepared formulations will be assessed for Bhasma Pariksha mentioned in Ayurveda. Organoleptic characters, Physicochemical parameters and Particle size distribution analysis, SEM –EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), and GCMS (Gas Chromatography Mass Spectroscope) will be evaluated. To assess the relative oral bioavailability of Praval Pishti & Praval Bhasma study will be conducted in healthy volunteers and will be compared with the standard calcium supplement.
 Observation and results: The study will be assessed for its relative oral bioavailability in healthy Volunteers by using unpaired “t” Test, One-way ANOVA.
 Conclusion: The pharmaceutical study of Praval Bhasma and Praval Pishti will provide the standard parameters and comparative evaluation with standard will generate evidence for better bioavailability.
Highlights
Ayurveda, the science of life is well known age old documented Indian system of Medicine
Most emphasis is given regarding the therapeutic uses of mercurial, mineral and metallic preparations including calcium containing formulations indicated in various disorders [2]
Calcium compounds are known in Ayurveda sciences since 2nd Century BC but Praval is in use from 8th century
Summary
The science of life is well known age old documented Indian system of Medicine. Calcium compounds are known in Ayurveda sciences since 2nd Century BC but Praval is in use from 8th century. Praval is a known calcium compound described under the Sudha Varga (group of calcium drugs). Praval (coral) is a very usually occurring calcium form It is rich source of calcium & minerals. As per text it can be converted into two formulas which are bhasma (calcinated ash) and pishti(powdered form without agni).These forms may have different rate of immersion. Organoleptic characters, Physicochemical parameters and Particle size distribution analysis, SEM –EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), and GCMS
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