Abstract
Background: Shukti (Oyster) is a very commonly occurring calcium form. It is rich source of calcium & minerals. As per text it can be converted into two forms which are bhasma (calcinated ash) and pishti (powdered form without agni).These forms may have different rate of absorption. This needs to be studied.
 Aim: To study Pharmaceutico-analytical study of Muktashukti pishti & Muktashukti bhasma and comparative evaluation of their relative oral bioavailability.
 Materials and methods: The two formulations will be prepared from shukti (oyster). By triturating with Gulabjala Muktashukti pishti will be prepared and by traditional puta method Muktashukti bhasma will be prepared. The prepared formulations will be assessed for Bhasma Pariksha mentioned in Ayurveda. Organoleptic characters, physicochemical parameters and Particle size distribution analysis, SEM-EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), GCMS (Gas Chromatography Mass Spectrometry) will be evaluated. To assess the relative oral bioavailability of Muktashukti pishti & Muktashukti bhasma study will be conducted in healthy volunteers and will be compared with the standard calcium supplement. The study will be conducted in between two test groups and standard group.
 Observation and results: The analytical parameters will be assessed and compared in Muktashukti bhasma and Muktashukti pishti. For relative oral bioavailability Blood serum calcium will be assessed in all three groups. By applying unpaired “t” Test, One-way ANOVA the statistical significance can be measured.
 Conclusion: The pharmaceutical & analytical study of Muktashukti pishti and Muktashukti bhasma will provide the standard parameters and clinical comparative evaluation with standard will generate evidence for better bioavailability.
Highlights
Rasashastra & Bhaishajya Kalpana is one among the branches of Ayurveda, which deals with Ayurvedic pharmaceutics
Most emphasis is given with respect to the therapeutic uses of mercurial, mineral and metallic medicines including calcium containing formulations specified for various disease conditions [2]
Observation & Results: The pharmaceutically prepared Muktashukti pishti and Muktashukti bhasma will be analyzed for organoleptic parameters and physichochemical parameters
Summary
Rasashastra & Bhaishajya Kalpana is one among the branches of Ayurveda, which deals with Ayurvedic pharmaceutics. Bhasma is a metallic or mineral preparation treated with specific liquid which are mostly juice, decoction or urine of animals & exposed to quantum of heat according to their suitable properties known as puta. It is an ash obtained through incineration. It is rich source of calcium & minerals As per text it can be converted into two forms which are bhasma (calcinated ash) and pishti (powdered form without agni).These forms may have different rate of absorption. Materials and methods: The two formulations will be prepared from shukti (oyster). Organoleptic characters, physicochemical parameters and Particle size distribution analysis, SEM-EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), GCMS
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