Abstract
The opiate family of receptors is believed to consist of the μ, δ, κ and σ subtypes. Autoradiographic studies have been conducted to define the distribution of the μ and δ receptors. However, due to the lack of a selective ligand definitive studies have not been reported for the κ receptor. Recently such a ligand was discovered and characterized. Results are presented in which the distribution of κ receptors in guinea pig brain slices were determined using autoradiographic techniques and its distribution compared to that of a typical μ ligand. The results demonstrate numerous differences between the two opioid systems. The κ receptors predominate in the prefrontal cortex, the nucleus accumbens, and deep cortex; whereas the μ receptors have a more intense, broader and different distribution.
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