Comparative morphofunctional visualization of the manifestations of chronic bacterial and radiation bladder injuries

Abstract

Comparative morphofunctional and histological visualization of bladder wall lesions in 15 patients with chronic bacterial cystitis and in 15 patients with chronic radiation cystitis using positron emission tomography - computed tomography (PET/CT) was performed. The studies have revealed significant differences in the parameters of blood flow and tissue metabolism in patients with these forms of bladder lesions. In patients with chronic bacterial cystitis, an increase in the frequency of urination was accompanied by a decrease in the capacity of the bladder under conditions of a decrease in the velocity of arterial and venous blood flow in its wall as compared with the control. At the same time, at the cellular-molecular level in the bladder wall, no significant metabolic abnormalities, assessed by the SUVmax indicator, were revealed. Chronic radiation cystitis was characterized by a significant increase in the rate of systolic and diastolic blood flow in the bladder wall, its thickening and hypermetabolism of 18F-FDG.