Abstract
Glutamic acid inhibits the utilization of aspartic acid in reactions concerned with the biosynthesis of pyrimidines as well as threonine in Leuconostoc dextranicum 8086 and with the biosynthesis of lysine, threonine, and to some extent pyrimidines in Lactobacillus arabinosus 17-5. Cysteic acid prevents the utilization of aspartic acid in reactions involved in the biosynthesis of these end products in both organisms. Since glutamic acid does not prevent the utilization of precursors of aspartic acid such as bicarbonate and oxalacetate which reverse cysteic acid inhibition competitively, different points of action with cysteic acid probably acting subsequent to glutamic acid are involved. The synergistic effects of combinations of the two inhibitors on L. arabinosus 17-5 offers further evidence for the involvement of a sequence of inhibitions.
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