Abstract
Cryogenine was a noncompetitive inhibitor of furtrethonium in isolated rat jejunum, while both diphenhydramine and cyproheptadine displayed mixed competitive-noncompetitive activity. All three compounds were relatively specific competitive antagonists of histamine in isolated guinea pig uterus, although each was capable of noncompetitive activity at high bath concentrations. Cryogenine and cyproheptadine had noncompetitive antihistaminic activity on guinea pig terminal ileum, while diphenhydramine exhibited mixed competitive-noncompetitive activity. Diphenhydramine appeared to be a fairly specific competitive antagonist of serotonin in rat uterus, while cryogenine was relatively noncompetitive. Cyproheptadine displayed mixed competitive-noncompetitive antiserotonin activity in this same tissue.
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