Abstract
AbstractWhen anaphylactic smooth muscle contraction (Schultz‐Dale reaction) was produced in ileum and uterus of the rat and guinea pig, it led to release of a substance which had contractile effect on guinea‐pig ileum but not on highly 5‐HT sensitive rat uterus. Following the Schultz‐Dale reaction, the tissues showed no significant changes in 5‐HT or histamine content when compared to controls from the same animals. However, the individual variation in amine content was high. Sensitized rat and guinea‐pig tissues, when incubated with antigen, exhibited no measurable release of 5‐HT. A decrease of the very low 5‐HT content of rat uterus was, however, noted when uteri from many animals were pooled and incubated. Histamine was liberated from uterus of both rat and guinea pig but not from ileum. It is concluded that 5‐HT is probably not involved in the Schultz‐Dale reaction in the guinea pig though it may be partly responsible for the anaphylactic contraction of rat uterus.
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