Comparative histophysiological study the effective treatment of induced eczema in rats that treated with Lanolin and glycerine with Vaseline in rats

Abstract

The present study has been designed to evaluate the potent role of healing efficacy of lanolin(which is also called wool wax), is an oily product secreted by the sebaceous glands beneath theskin of sheep which is have anti-inflammatory, anti-microbial, skin protecting properties, a fortyeightmature albino rats (weighted 250-350 g) were randomly assigned to two groups; control groupand eczema group which is induced by 99.9% pure acetone. By squad cotton and put it on shavedskin, after 3 days of acetone application the eczema group were divided randomly into two equalgroups each group 16 rats, treat these 32 rats with glycerin and lanolin, after 24h five rats from eachgroup were sacrificed, and remaining rats were treated with glycerin and lanolin for 72h and thensacrificed at the third day, the histopathology there is a lot of histopathological changes occur intissue section in eczematous skin in comparison with control section; there were obvious thicknessand enlargement in the length of outermost layer of skin, also there is fissures and cracks in theepidermal layer due to the dryness of skin and aggregation of inflammatory cells. And as well askeratinization of epithelial layer and changes in skin color, the results indicate there were optimumhealing effect of lanolin group in compare with glycerin group after 72h, Showed back the outermost layer of the skin to its normal length, also decrease in inflammatory cells number.