Abstract
IntroductionPreoperative functional mapping in the vicinity of brain lesion is of high importance for avoiding complications in surgical management. However, space-occupying lesions may lead to functional reorganization or decreased BOLD activity.MethodsTherefore in 13 patients with cerebral gliomas or brain arterio-venous malformations/ hemangioma fMRI- and MEG-based cortical localizations of motor and somatosensory cortical activation pattern were compared in order to investigate their congruency.ResultsLocalization of cortical sensorimotor areas with fMRI and MEG showed good congruency with a mean spatial distance of around 10 mm, with differences depending on the localization method. The smallest mean differences for the centroids were found for MEF with MNE 8 mm and SEF with sLORETA 8 mm. Primary motor area (M1) reorganization was found in 5 of 12 patients in fMRI and confirmed with MEG data. In these 5 patients with M1-reorganization the distance between the border of the fMRI-based cortical M1-localization and the tumor border on T1w MR images varied between 0–4 mm, which was significant (P = 0.025) different to the distance in glioma patients without M1-reorganization (5–26 mm).ConclusionOur multimodal preoperative mapping approach combining fMRI and MEG reveals a high degree of spatial congruence and provided high evidence for the presence of motor cortex reorganization.
Highlights
Preoperative functional mapping in the vicinity of brain lesion is of high importance for avoiding complications in surgical management
Our multimodal preoperative mapping approach combining Functional magnetic resonance imaging (fMRI) and MEG reveals a high degree of spatial congruence and provided high evidence for the presence of motor cortex reorganization
All data for comprehension the study is available within the manuscript
Summary
Preoperative functional mapping in the vicinity of brain lesion is of high importance for avoiding complications in surgical management. Space-occupying lesions may lead to functional reorganization or decreased BOLD activity. Preoperative characterization of the functional anatomy in the vicinity of the lesion is of high importance for effective surgical management. Space-occupying lesions may lead to functional reorganization and alter the topographic organization of the cortex [3,4]. Previous studies provided examples for lesion-induced brain plasticity leading to considerable regional shifts of functional brain areas [5,6,7,8,9,10,11]. Lesion-induced transhemispheric cortical reorganization to homologous brain regions (homotopic reorganization) in adult patients is considered controversial in the scientific community [12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
