Abstract
Introduction: The purpose of this in vitro study was to evaluate the concentration dependent effect of proton pump inhibitors on the action of calcium hydroxide against E. faecalis using a broth dilution study. Methods: Calcium hydroxide at a concentration of 16 mg/ml, pantoprazole and Lansoprazole at a concentration of 1 mg/ml made into dilutions of 6.25 and 25 μg/ml was incorporated into a broth containing E. faecalis and spectrophotometrically analysed at 630 nm at two time parameters of 12 hours and 24 hours. Results: At 12 hours there was statistically significant growth inhibition by group 5 (calcium hydroxide and lansoprazole 6.25 μg/ml). At 24 hours,the maximum Inhibition of E. faecalis was demonstrated by group 2 (calcium hydroxide and chlorhexidine 2%) and group 5 (calcium hydroxide and lansoprazole 6.25 μg/ml). Conclusion: Concentration dependent usage of proton pump inhibitors along with calcium hydroxide have potential in the eradication of persistent apical periodontitis.
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