Abstract
ABSTRACT%Purpose: The patients with cleft lip and palate have a higher risk of cervical vertebrae anomalies than do patients in general population. The aim of present study was to determine the prevalence of various upper cervical spine anomalies in different type of clefts.Procedures: Lateral cephalograms of 128 patients (66 males, 62 females) with cleft lip and palate, and 125 (60 males, 65 females) non syndromic patients without cleft lip and palate were selected at random from archive. Cephalograms of the patients were traced and the diagnosis of any cervical vertebrae anomaly was noted. Anomalies were categorized as either: posterior arch deficiency or fusions.Main findings: Prevalence of cervical vertebrae anomalies in the c lef t group was 20. 3% while it was 6.4% in the control group. Further cervical vertebrae anomalies were 16.6% in the CPO group, 19.1% in the BCLP group, and 22.2% in the UCLP group.Conclusion: A higher prevalence of cervical vertebrae anomalies was observed in cleft lip and palate patients. The prevalenc e obser ved is 3 times more in clef t group than c ontrol group.How to cite this article: Datana S, Bhalla A, Kumar P, Roy SK, Londhe S. Comparative Evaluation of Prevalence of Upper Cervical Vertebrae Anomalies in Cleft Lip/Palate Patients: A Retrospective Study. Int J Clin Pediatr Dent 2014;7(3):168-171.
Highlights
Development of the head and face comprises one of the most complex events during embryonic development, coordinated by a network of transcription factors and signaling molecules together with proteins conferring cell polarity and cell-cell interactions
A higher prevalence of cervical vertebrae anomalies was observed in cleft lip and palate patients
Thrice as many individuals (20.3%) had cervical vertebrae anomalies when compared with the control group (6.4%) (Table 3)
Summary
Development of the head and face comprises one of the most complex events during embryonic development, coordinated by a network of transcription factors and signaling molecules together with proteins conferring cell polarity and cell-cell interactions. Disturbance of this tightly controlled cascade can result in a facial cleft where the facial primordia fail to meet and fuse or form the appropriate structures. The patients with cervical spine anomalies have a higher risk of developing CLP than do patients in general population.[3] The radiographic appearance of anomalies of cervical vertebrae has been described by several authors.[4,5] The aim of present study was to determine the prevalence of various upper cervical spine anomalies in different type of clefts
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