Abstract
The present study aimed to compare between the amniotic and pericardial membranes for the wound dressing models. Ten local breed rabbits have been used in the current study. They were divided into two main equal groups: Experiment (Amniotic and pericardial membranes) and control group. According to healing periods each group was subdivided into four subgroups (7, 14, 21 and 28) days post wounding. Specimens of amniotic membranes were collected from full term pregnant cows, and pericardium was obtained from abattoir immediately after slaughtering. The study was conducted on skin wound for experiment application site as full-thickness skin wounds (3×3 cm) were done on the dorsal thoracic sides. Histopathological evaluation of study depended on the degrees of inflammatory exudate, epithelialization, fibroplasia and type of leukocytes infiltration. Results revealed marked reduction of the inflammatory phase during all periods of post treatment with amniotic membrane, the degree of epithelization and fibroplasia in addition to angiogenesis were enhanced in amniotic and pericardial dressed wounds during period of 14 and 21 days. The study concluded that no significant differences are between the pericardial membrane and of amniotic membrane in wound healing of skin.
Highlights
Specimens of amniotic membranes were collected from full term pregnant cows, and pericardium was obtained from abattoir immediately after slaughtering
The macroscopic finding in control group was that the wound area contracted progressively at the experimental periods, the calculation of wound closure was 10%, 25%, 75% at days 7, 14, 21 respectively, while in second group (PG) the wound contracted progressively with time and the closure percent was 20%, 50% and 100% at same periods, and the pericardial membrane adhered to the center of the wound, in the third group (AG) the amniotic membrane more firmly adhered to the wound area and wound contraction and re-epithelization more rapidly and the closure percent was 35%, 50% and 100% at the same periods as shown in (Fig. 1)
The signs of regeneration was mild at the deepest part of dermis characterized by proliferation of fibroblast with marked angiogenesis (Fig. 5 and 6) (Table, 1); the present result revealed mild inflammatory reaction and angiogenesis during the 7th day, this agreed with (15 and 16) in amniotic treated rabbit, but the present study showed the infiltration of polymorphic nuclear leukocytes mainly neutrophils such records were reported by [14] in rabbits
Summary
The objective of this study was to compare pericardial membrane and amniotic membrane in acute skin wound
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