Abstract
Three Au-based nanomaterials (silica@Au nanoshells, hollow Au/Ag nanospheres andAu nanorods) were evaluated for their comparative photothermal efficiencies atkilling three types of malignant cells (A549 lung cancer cells, HeLa cervix cancercells and TCC bladder cancer cells) using a CW NIR laser. Photodestructiveefficiency was evaluated as a function of the number of nanoparticles required todestroy the cancer cells under 808 nm laser wavelength at fixed laser power. Ofthe three nanomaterials, silica@Au nanoshells needed the minimum number ofparticles to produce effective photodestruction, whereas Au nanorods neededthe largest number of particles. Together with the calculated photothermalconversion efficiency, the photothermal efficiency rankings are silica@Au nanoshells > hollow Au/Agnanospheres > Au nanorods. Additionally, we found that HeLa cells seem to present better heat tolerancethan the other two cancer cell lines.
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