Abstract
Aim:Fasciolosis is a parasitic disease caused by Fasciola spp. of the family Fasciolidae (trematodes) characterized by bottle jaw, anemia, progressive debility, and potbelly condition. There are many aspects of fasciolosis remaining unknown thus hemato-biochemical alterations in closantel, triclabendazole + ivermectin, and oxyclozanide + levamisole treated goats were studied.Materials and Methods:A total of 40 naturally fasciolosis infected goats having egg per gram more than 100 were randomly divided into four groups. Goats of Group I-III were treated with three different anthelmintics, whereas, goats of Group-IV were kept as control or untreated. Whole blood, serum, and fecal samples were collected on 0, 7th, and 30th day of treatment.Results:During the study, values of hemoglobin, total erythrocyte count, pack cell volume, and total protein were significantly elevated to their normal levels in anthelmintics treated groups. Whereas, values of total leukocyte count, aspartate transaminase (AST), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT) were significantly reduced to their normal level in anthelmintics treated groups. The efficacy of closantel (T1), triclabendazole + ivermectin (T2), and oxyclozanide + levamisole (T3) was 99.63%, 100%, and 94.74% and 100%, 100%, and 97.38% on 7th and 30th day of treatment, respectively.Conclusions:Fasciolosis in goats can be diagnosed on the basis of fecal sample examination, but alterations in important biomarkers such as AST, GGT, and LDH are also helpful for early diagnosis. The use of newer anthelmintic either alone or in combination showed a higher therapeutic response in fasciolosis of goats.
Highlights
Parasitic infections pose a serious health threat and limitation to the productivity of small ruminants due to the associated morbidity, mortality, cost of treatment, and control measures
Goats of Group I-III were treated with three different anthelmintics, whereas, goats of Group-IV were kept as control or untreated
Fasciolosis in goats can be diagnosed on the basis of fecal sample examination, but alterations in important biomarkers such as aspartate transaminase (AST), gamma-glutamyl transferase (GGT), and lactate dehydrogenase (LDH) are helpful for early diagnosis
Summary
Parasitic infections pose a serious health threat and limitation to the productivity of small ruminants due to the associated morbidity, mortality, cost of treatment, and control measures. Among various parasitic infections of small ruminants, fasciolosis is the most important pathogenic parasitic infection which is widely distributed in India causing severe infection, anemia, and hypoalbuminemia. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
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