Abstract
Aim:This study was conducted to evaluate the possible association between values of certain serum biochemical parameters and seropositivity against Anaplasma marginale in dairy cows.Materials and Methods:Serum samples from 60 seropositive and 40 seronegative cows were used to determine the values of beta-hydroxybutyrate (BHB), glucose, creatinine, blood urea nitrogen, total protein, albumin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT) using commercially available kits and reagents. The serostatus of cows against A. marginale was determined using a commercially available cellular enzyme-linked immunosorbent assay kit according to the manufacturer’s recommendations. Significant differences in serum biochemical values between seropositive and seronegative groups were evaluated using independent Student’s t-test. Possible associations between the serostatus of the cows and different biochemical parameters were evaluated using univariate followed by multivariate logistic regression analyses.Results:There was a statistically significant increase (p≤0.05) in values of total protein, BHB, LDH, and AST in seropositive cows compared to seronegative cows while a non-significant increase in values of ALP, ALT, and GGT was detected in seropositive cows. A strong correlation (R=0.69) between serum levels of BHB, LDH, and AST and seropositivity against A. marginale was detected.Conclusion:There is evidence of a possible association between A. marginale infection and liver damage/hepatic fatty degeneration in dairy cows. Further studies, however, are required to elucidate the exact pathophysiological mechanisms of this relationship.
Highlights
Anaplasma marginale, the causative agent of anaplasmosis, is tick-borne, obligate intraerythrocytic rickettsial bacteria [1,2,3]
Materials and Methods: Serum samples from 60 seropositive and 40 seronegative cows were used to determine the values of beta-hydroxybutyrate (BHB), glucose, creatinine, blood urea nitrogen, total protein, albumin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT) using commercially available kits and reagents
Possible associations between the serostatus of the cows and different biochemical parameters were evaluated using univariate followed by multivariate logistic regression analyses
Summary
The causative agent of anaplasmosis, is tick-borne, obligate intraerythrocytic rickettsial bacteria [1,2,3]. The disease is considered endemic in most tropical and subtropical regions of the world, including South and Central America, the USA, Europe, Africa, Asia, the Middle East, and Australia [2,4]. The estimated prevalence of anaplasmosis has been found to vary between 30% in endemic areas and 100% in certain tropical regions [5]. Anaplasmosis is capable of causing significant economic losses due to high morbidity, mortality, reduced production, and losses associated with treatment and control measures [2,6]. Several risk factors have been identified, including
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