COMPARATIVE EFFECT OF METHALONIC EXTRACT OF SYRIAN FENUGREEK AND NIGELLA SATIVA SEEDS ON SOME BIOCHEMICAL PARAMETERS IN MALE DIABETIC RABBITS

Abstract

Present study investigated the effect of methanolic extracts of Fenugreek and Nigella Sativa seeds on blood glucose, total cholesterol and triglyceride, LDL, HDL levels in alloxan diabetic rabbits. The experiment was carried out on 42 of Male rabbits divided into7 groups 6 animals of each: -The first group was kept as normal control. - The second group was given orally the methanolic extract of and Nigella Sativa seeds 1/10 LD50. -The third group was given orally the methanolic extract of Nigella Sativa seeds 1/5 LD50. - The forth group was given orally the methanolic extract of Fenugreek seeds 1/10 LD50. - The fifth group was given orally the methanolic extract of Fenugreek seeds 1/10 LD50. - The six group was rendered diabetic and treated with insulin. - The seven group was diabetic by intraperitoneal injection of alloxan (150 mg/kg b.wt.) and left without treatment. Blood samples were collected at 1,20,40,60 days for determination of glucose, total cholesterol, triglyceride, LDL and HDL levels. The obtained results showed that oral administration of methanolic extracts of methanolic extracts of Fenugreek and Nigella Sativa seeds induced significantly (p < 0.05) decreased blood glucose, total cholesterol, triglyceride and LDL in all remediation experiment groups Especially (third, fifth groups) comparative to the diabetic control group, Methanolic extracts of Fenugreek and Nigella Sativa seeds induced significantly (p < 0.05) increase in HDL in all remediation experiment groups especially (third and fifth groups) in comparative to the diabetic control group.