Comparative description of the levels of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 in patients with 5D stage chronic kidney disease and in patients with anterior abdominal wall hernias

Abstract

Objective. To determine the levels of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in the plasma of patients with 5D stage chronic kidney disease (CKD) and in patients with anterior abdominal wall hernias.Materials and methods. Patients with end-stage chronic kidney disease and patients with anterior abdominal wall hernias were included into the study. MMP-1 and TIMP-1 plasma concentrations were determined by enzyme-linked immunosorbent assay.Results. The analysis of the plasma of the patients with end-stage CKD and with anterior abdominal wall hernias shows a statistically significant increase in the level of MMP-1 when compared to that of the patients of the comparison group: 7.98 ng / ml and 8.35 ng / ml, respectively (p ˂ 0. 0001). The plasma level of TIMP-1 (158.85 ng / ml) was statistically significantly higher in the patients with 5D CKD than in the patients with anterior abdominal wall hernias — 33.16 ng / ml and in the comparison group — 73.46 ng / ml (p ˂ 0.001). At the same time, the TIMP-1 level was determined statistically significantly higher in the comparison group than in the patients with anterior abdominal wall hernias (p ˂ 0.001).Conclusion. The obtained patterns may indicate an increased breakdown of type I collagen and interstitial substance in patients in the end-stage of CKD and in patients with anterior abdominal wall hernias.