COMPARATIVE CORRELATION OF MARKERS OF INFLAMMATORY METAMORPHISM IN THE PERIPHERAL BLOOD IN DORSOPATHY OF DIFFERENT GENESIS

Abstract

A blood test for acute phase proteins and inflammatory markers is a comprehensive study of various proteins, the level of which in the blood rises during various inflammatory processes in the body. Dorsopathy is a common pathology accompanied by aseptic inflammation in the spine, but has not been studied for markers of inflammation. To study the indicators and comparative correlation of markers of inflammatory metamorphism in the peripheral blood of patients with chronic pain syndrome in dorsopathies of various origins. 320 patients with chronic pain syndrome with dorsopathies of various origins, who are being treated in the neurology department of the City Medical Association of Samarkand in the period from 2018 to 2021, were selected. The research methods used where blood tests for acute phase proteins and inflammatory markers: fibrinogen, C–reactive protein, interleukin–1β. The results of the study obtained in the study of patients with dorsopathies of compression–ischemic genesis, brucellosis, rheumatic and herpetic genesis showed that fibrinogen, C–reactive protein, interleukin–1β can be chosen as an additional biochemical criterion for the differential diagnosis of patients with chronic pain syndrome in dorsopathies of various origins. In patients with chronic pain syndrome in dorsopathies of compression–ischemic genesis, brucellosis, rheumatic and herpetic genesis, the detected concentrations of fibrinogen, C–reactive protein and interleukin–1β in the blood serum indicated various indicators of the presence of an inflammatory process, provoking chronic pain, indicating an inflammatory nature, which determines the chronic course and nature of pain.