Abstract
Aim - to estimate the remote results of treatment of obliterating atherosclerosis of arteries of the lower extremities of the II stage in patients of advanced and senile age after the combined use of ozone therapy and gravitational therapy. Materials and methods. A prospective randomized study in three parallel groups comprised 139 patients. The first group (n = 57) received standard medical therapy in combination with ozone therapy; the group was divided into two subgroups: the patients of subgroup 1a (n = 28) received intravenous ozonated physiological solution, in subgroup 1b (n = 29) - major ozonated autohemotherapy (MOA). Patients of the second group (n = 62) underwent comprehensive treatment, including gravitational therapy (GT) in addition to medical ozone. In this group we also identified two subgroups: subgroup 2a (n = 31), in which the patients received standard medical therapy in combination with ozonated physiological solution and gravitational therapy, and subgroup 2b (n = 31), in which the treatment was amplified by MOA and GT. The third group was the control group (n = 20) that included patients who received only standard medical therapy. Dynamics of changes of disease stages and the number of surgeries in the remote period was estimated (up to 7 years). Results. After 6 months of follow-up observation, the distribution of the disease stages among the patients did not differ significantly (p> 0.05) from the initial amount. Analysis of survival and probable risks after 7 years of follow-up by Cox regression method in relation to the applied method of treatment revealed maximum efficiency of combined treatment in subgroup 2a. Conclusion. As a result of complex conservative treatment, including ozonotherapy and gravitational therapy, the probability of surgical interventions as well as disease stage advancing were effectively reduced.
Highlights
Цель — оценить отдаленные результаты лечения облитерирующего атеросклероза артерий нижних конечностей II стадии у пациентов пожилого и старческого возраста после сочетанного применения озонотерапии и гравитационной терапии
The first group (n = 57) received standard medical therapy in combination with ozone therapy; the group was divided into two subgroups: the patients of subgroup 1a (n = 28) received intravenous ozonated physiological solution, in subgroup 1b (n = 29) — major ozonated autohemotherapy (MOA)
Patients of the second group (n = 62) underwent comprehensive treatment, including gravitational therapy (GT) in addition to medical ozone. In this group we identified two subgroups: subgroup 2a (n = 31), in which the patients received standard medical therapy in combination with ozonated physiological solution and gravitational therapy, and subgroup 2b (n = 31), in which the treatment was amplified by MOA and GT
Summary
Цель — оценить отдаленные результаты лечения облитерирующего атеросклероза артерий нижних конечностей II стадии у пациентов пожилого и старческого возраста после сочетанного применения озонотерапии и гравитационной терапии. Проспективное рандомизированное контролируемое исследование в трех параллельных группах у 139 пациентов. Первая группа (n=57) получала стандартную консервативную терапию в сочетании с озонотерапией; при этом группа была разделена на две подгруппы: больным подгруппы 1а (n=28) осуществляли внутривенное введение озонированного физиологического раствора (ОФР), подгруппы 1б (n=29) – большую аутогемоозонотерапию (БАТ). В этой группе также были выделены две подгруппы: подгруппа 2а (n=31), где больные получали стандартную консервативную терапию в сочетании с ОФР и ГТ, и подгруппа 2б (n=31) – в сочетании с БАТ и ГТ. В третью группу, контрольную, (n=20), вошли больные, получавшие только стандартную консервативную терапию. Оценивалась динамика изменений стадии заболевания и количество оперативных вмешательств в отдаленном периоде (до 7 лет). Aim — to estimate the remote results of treatment of obliterating atherosclerosis of arteries of the lower extremities of the II stage in patients of advanced and senile age after the combined use of ozone therapy and gravitational therapy
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