Abstract
Efferent physical therapy holds promise as an adjunct to the combination treatment of femoral fractures in young, working-age individuals. The aim of the study was to investigate the dynamics of bone turnover markers at different stages of femoral fracture consolidation in patients undergoing ozone therapy. The study enrolled 20 men (group 2, 47.8 ± 3.5 years) with a femoral shaft fracture (AO/ASIF 32А, 32В). The control group (group 1, 46.8 ± 3.7 years) comprised 10 healthy males. Subgroup 2a (n = 10) was assigned to receive standard therapy; subgroup 2b (n = 10) was assigned to receive standard therapy complemented by minor autohemotherapy (MAHT) at 20 mg/L ozone concentrations. On days 7, 30 and 90, fracture consolidation was assessed on the RUST scale and blood levels of С-terminal telopeptides of type I collagen (bCTx, pg/ml) and procollagen type I carboxy-terminal propeptide (PICP, ng/ml) were measured. On day 7, the total RUST score in subgroups 2a and 2b was 4 points; on day 30, it was 6.5 and 8.7 points, respectively, and on day 90, it reached 10 and 11.5 points, respectively. Bone mineral density was as high as 90% in the MAHT subgroup vs. 78% in subgroup 2а, indicating faster bone healing. On day 30, bCTx levels in subgroup 2b were higher than in subgroup 2a (2289.4 [2145.3; 2365.4] vs. 1894.6 [1745.3; 2098.2], respectively. On day 7, PICP was significantly elevated in subgroup 2b in comparison with subgroup 2a; its levels peaked on days 30 and 90 (day 30: 268.3 [231.2; 286.3] vs. 183.2 [174.6; 195.6]; day 90: 584.6 [512.3; 589.3] vs. 351.2 [312.3; 369.4]. Thus, MAHT produces a positive effect on the quality and intensity of bone healing in men with isolated closed femoral shaft fractures.
Highlights
Efferent physical therapy holds promise as an adjunct to the combination treatment of femoral fractures in young, working-age individuals
This pilot study enrolled 20 male patients admitted to Chelyabinsk Regional Clinical Hospital for isolated closed displaced midshaft femoral fractures coded as 32A or 32B according to the AO/ASIF classification and as S72.3 according to ICD-10 [6]
Group 2a was assigned to receive standard therapy; group 2b was assigned to receive standard therapy complemented by minor autohemotherapy (MAHT), i.e. injections of ozoneenriched autologous blood
Summary
Efferent physical therapy holds promise as an adjunct to the combination treatment of femoral fractures in young, working-age individuals. The study enrolled 20 men (group 2, 47.8 ± 3.5 years) with a femoral shaft fracture (AO/ASIF 32А, 32В). On days 7, 30 and 90, fracture consolidation was assessed on the RUST scale and blood levels of С-terminal telopeptides of type I collagen (bCTx, pg/ml) and procollagen type I carboxy-terminal propeptide (PICP, ng/ml) were measured. MAHT produces a positive effect on the quality and intensity of bone healing in men with isolated closed femoral shaft fractures. В динамике на 7-е, 30-е, 90-е сутки определяли интенсивность консолидации (по шкале RUST), С-концевые телопептиды коллагена I типа (bCTx, пг/мл) в крови, С-концевой пропептид проколлагена I типа (PICP, нг/мл). В. Осиков — концепция и дизайн исследования, анализ полученных данных, написание текста, редактирование рукописи; Е. Все авторы внесли существенный вклад в проведение исследования и подготовку статьи, прочли и одобрили финальную версию перед публикацией
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