COMPARATIVE ANTIMICROBIAL ACTIVITY OF SEVEN DISINFECTANTS MARKETTED IN LAGOS AGAINST CLINICAL BACTERIA ISOLATES

Abstract

Antimicrobial effects of seven disinfectants were studied against a wide range of clinical bacterial isolates using Agar dilution method to determine the minimum inhibitory concentration (MIC). The active compounds of the disinfectants according to their manufacturer were D1-(Chloroxylenol 4.8% w/v), D2-(Chlorhexidinegluconate 0.3g and Centrimide 3.0% w/v), D3- (Centrimide 3.0% w/v and Chlorhexidinegluconate 0.3g), D4- (Dichloroxylenol 2% w/v), D5- (Sodium hypochlorite 3.85% m/v) and D6- (Halogenated phenol 0.68% and Sodium salicylate 0.052%). The test organisms were clinical isolates of Escherichia coli, Staphylococcus aureus and Salmonella enterica serotype Typhi. The MICs of the disinfectants ranges from 0.003%v/v to 2.5%v/v. This study showed that some of the disinfectants tested have strong bactericidal effect against the clinical bacteria isolates while others were less effective. Results also revealed that D2 which is made of Chlorhexidinegluconate 0.3g and centrimide 3.0% w/v has the greatest antibacterial activity. Likewise, antibacterial effects of the disinfectants are not only dependent on the types of disinfectant but also on their concentrations