Abstract
Suledoxide represent a novel antithrombotic agent with multiple sides of actions on blood coagulation process. This drug has been used widely in various vascular indications. Suledoxide has been recently shown to produce therapeutic effects in diabetic nephropathy. Unlike LMWH, this agent can also be used orally. The purpose of this study was to compare the anticoagulant effects of Suledoxide with a LMWH Enoxaparin which is use mainly via subcutaneous route. Suledoxide represent of mixture of fast mobilizing heparin 80% and 20% Dermatan Sulfate. Within average molecular weight of 20.8 kDa. Suledoxide may be effective in subcutaneous indications. In order to investigate the anticoagulant effect of Suledoxide this agent was supplemented to citrated whole blood at concentration of 0–25 ug/ml such blood test ha PT, aPTT, Heptest, and Thrombin time were measured. This agent was compared Enoxaparin at equigravimetric concentrations.In comparison to Enoxaparin and Suledoxide produced a stronger anticoagulant effect in the PT assay. Similarly Suledoxide produce a much stronger anticoagulant effect in the aPTT assay. In the Heptest assay, Suledoxide produced anticoagulant effects. Thrombin Time results is also much stronger with Suledoxide in comparison to Enoxaparin.These results highly suggest that Suledoxide is a relatively stronger anticoagulant than Enoxaparin. Suledoxide may also exhibit subcutaneous bioavailability. These results warrant further investigation on Suledoxide in Pharmacologic studies.
Published Version
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