Abstract
An analysis of ribosomal protein pseudogenes in the four mammalian genomes reveals no correlation between number of pseudogenes and mRNA abundance.
Highlights
The availability of genome sequences of numerous organisms allows comparative study of pseudogenes in syntenic regions
We focus on the largest family of pseudogenes, processed pseudogenes of ribosomal proteins (RPs)
We investigated the degree to which processed RP pseudogenes are conserved among the four species
Summary
We report the first large-scale comparative analysis of ribosomal protein pseudogenes in four mammalian genomes (human, chimpanzee, mouse and rat). To this end, we have assigned these pseudogenes in the four organisms using an automated pipeline and make the results available online. Analysis of pseudogenes in syntenic regions between species shows that most are conserved between human and chimpanzee, but very few are conserved between primates and rodents. Detailed analysis shows that one of them, the pseudogene of RPS27, is likely to be a protein-coding gene. This is significant as previous reports indicated there are exactly 80 ribosomal protein genes encoded by the human genome
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