Abstract
Objective:to study the infection of the adult and children’s population of the Rostov and Astrakhan regions by the bacteria Helicobacter pylori, to determine the frequency of H. pylori pathogenicity factors in different age groups of the population.Materials and methods:118 adults and 112 children were examined. Te presence of H. pylori DNA and the pathogenicity factors of CagA and VacA in the biopsy material of the mucous membrane of the antrum of the stomach was determined by PCR.Results:a signifcantly smaller percentage of H. pylori–positive patients is characteristic of the child population. Te prevalent H. pylori genotype in the infant population is the avirulent genotype Vac s2m2 (60%) (χ2: p <0.005). Genotype CagA + VacAs1 VacAm1 is a marker of peptic ulcer for adult population of the Rostov region.Conclusion:Te conducted studies allowed to establish differences in infection of the population with H. pylori bacteria and the frequency of the distribution of virulent genotypes depending on the region, age and severity of the pathology.
Highlights
Objective: to study the infection of the adult and children’s population of the Rostov and Astrakhan regions by the bacteria Helicobacter pylori, to determine the frequency of H. pylori pathogenicity factors in different age groups of the population
The presence of H. pylori DNA and the pathogenicity factors of CagA and VacA in the biopsy material of the mucous membrane of the antrum of the stomach was determined by PCR
Results: a significantly smaller percentage of H. pylori–positive patients is characteristic of the child population
Summary
Сравнительный анализ генотипов штаммов Helicobacter pylori в Ростовской и Астраханской областях. Цель: изучить инфицированность бактериями Нelicobacter pylori взрослого и детского населения Ростовской и Астраханской области, определить частоту встречаемости факторов патогенности H. pylori у разных возрастных групп населения. Для взрослого населения Ростовской области генотип CagA+VacA s1VacA m1 является маркером язвенной болезни. Objective: to study the infection of the adult and children’s population of the Rostov and Astrakhan regions by the bacteria Helicobacter pylori, to determine the frequency of H. pylori pathogenicity factors in different age groups of the population. Genotype CagA + VacAs1 VacAm1 is a marker of peptic ulcer for adult population of the Rostov region. Conclusion: The conducted studies allowed to establish differences in infection of the population with H. pylori bacteria and the frequency of the distribution of virulent genotypes depending on the region, age and severity of the pathology
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