Comparative Analyses of DHA‐Phosphatidylcholine Forage and Liposomes on Alzheimer's Disease in SAMP8 Mice

Abstract

The present work comparatively evaluates the efficacy of docosahexaenoic acid – phosphatidylcholine (DHA‐PC) forage and liposome on Alzheimer's disease (AD) in the senescence‐accelerated prone 8 (SAMP8) mice and illustrates the potential mechanism. The dose of DHA‐PC in forage group (1% of total diets) is equal to that of liposome group. The results of Morris maze test show that both DHA‐PC forage and liposome obviously alleviated cognitive impairment (P < 0.05). Moreover, the administration of DHA‐PC liposome shows advantage than forage in reducing β‐amyloid (Aβ) accumulation (P < 0.05). Meanwhile, DHA‐PC forage exhibits excellent inhibition on the IL‐1β protein expression (P < 0.05) and improvement in the protein levels of SYN and BDNF (P < 0.05). These data are the first to perform comparative analysis of DHA‐PC forage and liposome on AD.Practical Applications: The outcomes in the present study might help to understand the bioactivities of DHA‐PC forage and liposomes, which might exert potential application value for dietary supplement with neuroprotective effects.Both docosahexaenoic acid – phosphatidylcholine (DHA‐PC) forage and liposome shows benefits in alleviating Alzheimer's disease development in senescence‐accelerated prone 8 mice by inhibiting β‐amyloid generation, oxidative stress, apoptosis, neural inflammation, and enhancing neurotrophins pathway in different degrees.