Comparative Activities and Toxicities II. : Sugar and Amino Acid Derivatives of Bis-(4-aminophenyl)-sulfone

Abstract

The acute toxicities and antibacterial activities of the various sugar derivatives of bis-(4-aminophenyl)-sulfone have been compared with those of several α-amino acid derivatives. For this purpose, it was necessary to synthesize α-amino acid derivatives and to place the reported toxicity values for the sugar derivatives on a standard basis. It was found that the α-amino acid substituents were less effective in reducing the toxicity of bis-(4-aminophenyl)-sulfone than the sugars, but there was a comparable retention of antitubercular activity with both types of derivatives.