Abstract
The compression behavior and compactibility of a novel triple-layer tablet formulation has been studied and the effect of punch velocity (50 mm s −2, 125 mm s −1, 250 mm s −1, and 500 mm s −1) on the compaction properties was also investigated using compaction simulator. The main formulation components were poly(ethylene oxide) (PEO), lactose, and theophylline. Heckel profiles of each layer as well as the combined layers were constructed, the porosity and tensile strength of the compacts were determined, and strain rate sensitivity (SRS) values were calculated. Results indicate that the formulation of each layer and the combined triple-layer tablet exhibited similar compression behavior, and the consolidation mechanism was shown to follow predominantly plastic deformation as evidenced by the shape of Heckel plots and high SRS values. The strain rate sensitivity for layer 1, 2, and 3 and combined triple-layer tablet was 16.2%, 26.1%, 19.3%) and 10.7%, respectively. The degree of compact densification and resistance to compressibility within the die cavity was influenced by production rate as evidenced from percent porosity reduction with increasing compaction pressure as well as varying punch velocity. Compact lamination was only observed at both high punch velocity (500 mm s −1) and compaction pressure. Furthermore, changes in tensile strengths and residual porosity as compression force was increased showed similar trends at constant punch velocities. It might be concluded that a successful design of triple-layer tablet formulation necessitates careful selection of plastic, brittle, and other desirable components to ensure comparable compactibility profiles.
Published Version
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