Comorbidity in children with gallstone disease

Abstract

According to the WHO report, in 44.0% of cases of the adult population, comorbidity is formed, which increases with the age of the patients. Meanwhile, early detection and impact on a single etiopathogenetic mechanism of comorbid diseases will not only reduce the number of diseases in one and the same patient, but also help solve the problem of polyprogmasia and disability of patients. In pediatric practice, there are isolated works devoted to the problem of comorbidity, in connection with which our studies on the study of comorbid conditions in children with cholelithiasis (cholelithiasis) are of particular interest.Purpose. The aim of this study was to improve the early diagnosis of comorbid diseases in children with cholelithiasis for the development of therapeutic and prophylactic measures and rehabilitation of patients with cholelithiasis.Material and methods. This study involved 146 children with cholelithiasis (GSD), selected based on the results of appeals to the consultative-polyclinic and inpatient departments of the State Budgetary Healthcare Institution of the Children’s Regional Clinical Hospital of Krasnodar. Children were divided into three groups according to the number of comorbid diseases. Group I consisted of 59 children, including 38 girls (26.0%) and 21 boys (14.4%), whose average age was 8.6 ± 4.5 years, with 3 comorbid diseases. Group II — 57 children, (29–19.7% girls and 28–19.2% boys, average age was 9.1 ± 4.4 years, with 5 comorbid diseases. Group III — 30 children (14–9.6% of girls and 16–11.0% of boys), the average age was 10.3 ± 4.7 years with 6 or more comorbid diseases.The clinical trial protocol was approved at a meeting of the ethnic committee of the KubSMU, Krasnodar.Conclusion. Comorbidity in children with gallstone disease is common. Among them, functional disorders of the biliary tract are in the lead. Among chronic diseases of the digestive tract, diseases of the upper sections of the digestive tract are significantly more common, and somewhat less often of the liver and pancreas. More than half of children with gallstones have comorbidity of other organs and systems, in particular, diseases of the upper respiratory tract and urinary system are more often determined. Comorbid diseases increase the severity of the condition and worsen the prognosis of the disease. Diagnosis of comorbid conditions should be thorough in order to select adequate therapy, taking into account the combination of drugs. At the same time, the environment is one of the risk factors for the development of children with gallstone disease.