Abstract
The circulating levels of β-carotene are modulated not only by sex, but also by autosomal gene variations and fruit intake. The aim of this study was to investigate the interactions between β-carotene metabolism-related gene single nucleotide polymorphisms (SNPs; genetic factors) and nutrient intake (environmental factors) relating to their effects on circulating β-carotene. The serum concentrations of β-carotene and the habitual food intake of 92 healthy Japanese adults were examined. All subjects were genotyped for three common SNPs: rs6564851 in the β-carotene 15,15′-oxygenase 1 (BCO1) gene, rs2278986 in the scavenger receptor class B member 1 (SCARB1) gene and rs362090 in the intestine-specific homeobox (ISX) gene. Univariate analysis revealed that the circulating β-carotene levels were significantly higher in rs6564851 GG homozygotes (p = 0.003). Additionally, the daily intake of β-cryptoxanthin was positively associated with the circulating β-carotene levels in female GG homozygotes of rs6564851 (p = 0.023), and the daily intake of α- and β-carotenes, and β-cryptoxanthin was significantly lower in female rs6564851 T allele carries than in female GG homozygotes (p = 0.009, 0.008, 0.009, respectively). The present study apparently indicates that higher circulating β-carotene levels in female rs6564851 GG homozygotes depend on carotenoid intake.
Highlights
More than 25 years ago, Dr Cutler found a significant positive correlation between the potential maximal lifespan of different primate species including humans and the concentration of carotenoids in their serum [1]
We evaluated the effects of three single nucleotide polymorphisms (SNPs) and the dietary intake of carotenoids on serum carotenoid levels in 92 Japanese adult volunteers (63 men and 29 women)
In the present study on a healthy adult Japanese population, we confirmed two previous findings: the serum concentration of β-carotene is higher in females than in males [4], and a regulatory SNP of the BCO1 gene significantly affects the circulating levels of βcarotene, which were higher in the GG homozygotes than in the T allele carriers [13]
Summary
More than 25 years ago, Dr Cutler found a significant positive correlation between the potential maximal lifespan of different primate species including humans and the concentration of carotenoids in their serum [1]. Rs6564851 in the BCO1 Gene Affects Carotenoid Daily Intake in Japanese performed [6], suggesting that circulating carotenoid levels depend on the amount of carotenoid intake prior to blood collection. Oxidative stress such as smoking is known to decrease the circulating level of β-carotene [7]. As shown in the literature, the circulating level of β-carotene in humans is influenced by several environmental factors
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
