Abstract
Background and Aims: Very rare loss-of-function mutations in the apolipoprotein C3 (APOC3) gene have been associated with low circulating apoC-III, low triglycerides, and reduced cardiovascular risk. However, these very rare mutations have also been related to low LDL cholesterol. We aimed to precisely analyze the impact of common APOC3 variants on circulating apoC-III, lipids, and on coronary artery disease in the largest sample so far.
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