Abstract
The remarkable improvement in survival of children with Wilms tumor over the past half century rests on the combined use of surgery, chemotherapy and radiotherapy with risk stratified protocols, with risk stratification based on the independently prognostic variables of tumor stage and histology. Ninety percent of children with Wilms tumor now survive with the use of these risk-adapted treatment protocols, protocols which aim to achieve maximal survival with minimal short and long term toxicity of treatment.
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