Abstract
AbstractSee related article in EMBO Molecular Medicine http://dx.doi.org/10.1002/emmm.201201516
Highlights
Through parallels with the normal development of the corresponding normal cell types the cancer stem cell (CSC) model can help describe the earliest steps in the tumourigenic process before a fully malignant tumour is formed
The tumours are believed to result from a disturbance in the mesenchymal-epithelial transition at the onset of nephron formation and several genome-wide expression and epigenetic studies have confirmed the similarity between cells found in Wilms’ tumours (WT) and cells at these earliest stages of nephron development
As many details about kidney development are known (Costantini & Kopan, 2010), WT are an excellent model to study the link between normal development and tumourigenesis through the role of CSC
Summary
Citation for published version: Hohenstein, P 2013, 'The stem and roots of Wilms' tumours', EMBO molecular medicine, vol 5, no. Link: Link to publication record in Edinburgh Research Explorer Document Version: Publisher's PDF, known as Version of record
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