Abstract
Commentary: The unliganded glucocorticoid receptor positively regulates the tumor suppressor gene BRCA1 through GABP beta.
Highlights
The study showed that addition of hydrocortisone, which binds the glucocorticoid receptor (GR), eliminates the interaction between GR and GABPβ, causing a deficiency of the GABP transcription factor to the BRCA1 gene, which decreases its expression, and increases the risk of breast cancer
We would like to propose a second mechanism by which stress causes a deficiency of the GABP transcription factor involving the presence of certain latent viruses in the cell
A close inspection of the numbers on the y-axis, Stress increases microcompetition causing cancer which are depicted logarithmically, suggests that the CMV P/E is about 150-fold stronger than the platelet-derived growth factor-b chain (PDGF-b) promoter
Summary
The unliganded glucocorticoid receptor positively regulates the tumor suppressor gene BRCA1 through GABP beta by Ritter, H. Commentary: The unliganded glucocorticoid receptor positively regulates the tumor suppressor gene Many studies showed that stress increases the binding of cortisol to the glucocorticoid receptor (GR) (Ritter et al, 2012). The study showed that addition of hydrocortisone, which binds the GR, eliminates the interaction between GR and GABPβ, causing a deficiency of the GABP transcription factor to the BRCA1 gene, which decreases its expression, and increases the risk of breast cancer (see Figure 1A).
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