Abstract
"Commentary: The ageing as a therapeutic target for Alzheimer's disease"
Highlights
Alzheimer’s disease (AD) is the most common form of dementia in the elderly and, in the absence of effective prevention and treatment, is estimated to affect 160 million people worldwide by 20501, leading to potential bankruptcy of the Medicare system
Both are still being explored in a number of clinical trials[2].These accumulating failures call into question the promise of targeting the formation and occurrence of amyloid plaques as a viable approach for treating AD
Since most of these chronic diseases appear when the body ages, does not it make sense to assume that they share common elements that should be combated? And is not that tantamount to combating / treating aging? In the last two decades, research on the molecular mechanisms of aging has led to a paradigm shift to such an extent that we can say that aging is not an unalterable process[13]
Summary
Alzheimer’s disease (AD) is the most common form of dementia in the elderly and, in the absence of effective prevention and treatment, is estimated to affect 160 million people worldwide by 20501, leading to potential bankruptcy of the Medicare system. Research on the basic biology of aging aims to understand mechanisms that cause organisms to decline in function over time and lead to increasing risk of morbidity and mortality.
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