Abstract
To be successful, the speculative scientific review must be provocative without being provoking. In the present instance, this goal has been achieved by a thoughtful attention to exposition: The author begins with scientifically indisputable facts from which he draws logical inferences; only then does he ask the reader's indulgence to follow his speculations. He concludes the review with a hypothesis that is especially attractive because it provides a novel explanation for the pathogenesis of Alzheimer's disease and because it is experimentally verifiable.
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