Abstract
In the last decade, researchers have searched for predictive surface markers of multipotent mesenchymal stromal/stem cells (MSCs) for ensuring improved therapeutic outcomes following cartilage damage in humans. However, we have achieved only limited progress because of the challenge presented by conflicting data. This commentary provides some evidence to prove a lack of success with current efforts, including an inconsistency in accepted surface markers and chondrogenic potential of MSCs as well as the tissue source–dependent MSC surface markers that correlate with chondrogenic potential. A brief discussion on these disputed topics and perspective about functionally predictive surface markers and standardization of analytic procedures are also highlighted.
Highlights
As a leading cause of disability among adults, osteoarthritis often results from a biochemical breakdown of articular cartilage in joints[1]
Human multipotent mesenchymal stromal/stem cell (MSC)-based cell therapy is expected to deliver a promising treatment for cartilage repair because of easy isolation of cells from mesenchymal tissues with higher proliferative and chondrogenic potential[3,4]
In vitro culture of MSCs must have the ability to adhere to plastic substrates; second, MSCs should express cluster of differentiation 73 (CD73), CD90, and CD105 (>95%), which are measured by flow cytometry
Summary
F1000 Faculty Reviews are written by members of the prestigious F1000 Faculty. They are commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. Any comments on the article can be found at the end of the article
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