Commentary on achievement of first life-saving xenoheart transplant.

Abstract

Two months of post-transplant survival were achieved in an end-stage heart disease patient with a porcine heart from a pig whose genome had been modified in 10 of its genes. This first-ever life-saving cardiac xenotransplantation was the result of decades of work and close coordination by researchers in genetic engineering, animal cloning, immunology, ex vivo organ perfusion, and thoracic surgery.