Comment on "Use of Carnosine for Oxidative Stress Reduction in Different Pathologies".

S V Jargin

doi:10.1155/2016/5250386

Abstract

I congratulate Prokopieva et al. for their review “Use of Carnosine for Oxidative Stress Reduction in Different Pathologies” [1]. The authors overview properties and biological effects of the antioxidant carnosine (Cn). Data on the use of Cn in various conditions are discussed. Special attention is given to the use of carnosine in neurologic, mental diseases and alcoholism. I have read the paper with a great interest. However, a comment seems to be necessary to formulate a praxis-relevant and evidence-based conclusion.

Highlights

To decide whether supplementation of a substance is indicated, the question should be answered whether there can be a deficiency of that substance and if yes, whether it can be compensated for by a diet modification
The Cn eye drops sold in Russia are relatively expensive; they are prescribed to aged patients
To support the placebo effect, patients may be advised that the natural products can supply their organism with Cn to drugs or dietary supplements

Summary

Introduction

To decide whether supplementation of a substance is indicated, the question should be answered whether there can be a deficiency of that substance and if yes, whether it can be compensated for by a diet modification. Tissue Cn concentrations are influenced by the diet and are lower in vegetarians than in the general population [2, 4]. If Cn concentration in body fluids is of importance, the incidence of corresponding conditions in vegetarians or population groups consuming less meat would be higher than average, which, to the best of our knowledge, has never been reported.

Results

Conclusion