Comment on 'A PET reconstruction formulation that enforces non-negativity in projection space for bias reduction in Y-90 imaging'.

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We read with great interest the paper by Limet al(2018Phys. Med. Biol.63035042) on bias reduction in Y-90 PET imaging. In particular, they proposed a new formulation of the tomographic reconstruction problem that enforces non-negativity in projection space as opposed to image space. We comment on the algorithm they derived from this formulation and bring some clarifications on the constraint that this algorithm respects.